Title: Unlocking Cell Membranes: DNA Nanocages as Transport Channels for Biomolecules

Nucleic acids are highly programmable materials ideal for creating nanoscale structures. Their biocompatibility and low production costs make them suitable for various biomedical applications. 

This work presents a DNA nanocage engineered to facilitate the selective transport of biomolecules across prokaryotic and eukaryotic cell membranes. The design enables the transfer of biomolecules, from single ions to larger proteins, bypassing natural pathways. We showcase a library of DNA motifs effective for transport in various cell types, including ion translocation in live neurons and transfer of larger biomolecules like green fluorescent protein (GFP) across brain cancer and stem cell membranes.

The versatility of this nanocage design offers promising opportunities for targeted drug delivery, biosensing, and improved intercellular communication, ensuring stability and precision in interactions with lipid bilayers.

https://engineering.purdue.edu/BME/People/ptProfile?resource_id=256061

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