Materials and Process Impact on Additive Manufacturing (3D Printing) of Pharmaceuticals
Abstract: Three-dimensional (3D) printing, a transformative technology known as additive manufacturing, is increasingly gaining traction in the pharmaceutical industry as an advanced manufacturing process. It enables personalized medicine through adjustable drug loading, complex dosage form design, on-demand production, and the creation of pills with multiple active pharmaceutical ingredients (APIs)., etc. where the current manufacturing processes follow one-size-fits-all approach unable to do that due to scientific and technological limitations. Among several types of printing systems, extrusion-based 3D printing is considered simple, low cost, scalable, and handles a wide range of materials. Pressure-assisted microsyringe (PAM), a micro extrusion-based 3D printing, is well suited for the pharmaceutical industry because it can handle materials at low temperatures. The PAM printing process involves the usage of the polymer as the primary functional excipient to prepare the ink and subsequently print the dosage structure or matrix (i.e., tablet, capsule, film, etc.). The challenge for PAM printing- is that to obtain a perfect 3D printed matrix, significant trial and error effort is required due to the materials and process impact on printing. In this research talk, research projects will be discussed, and how the challenges were attempted to minimize.
Bio: Dr. Mohammad Azad is an associate professor in the Chemical, Biological, and Bioengineering (CBBE) Department at North Carolina Agricultural and Technical State University (NCAT). He received his Ph.D. in Chemical Engineering from the New Jersey Institute of Technology (NJIT) and postdoctoral research at the Massachusetts Institute of Technology (MIT). He contributed to cutting-edge projects such as DARPA's "Pharmacy on Demand" program at MIT and NSF ERC center (Center for Structured Organic Particulate Systems, C-SOPS) at NJIT. Dr. Azad joined the CBBE department in the Fall of 2018, and his current research spans 3D printing, polymer processing, materials characterization, nanoparticles, and data analytics. His research is funded by DOD, NSF-SCH, and NSF Engines. Dr. Azad has authored 6 patents, 3 book chapters, and 26 journals and serves on the editorial board of the Advanced Powder Technology Journal. He has mentored 9 graduate and 19 undergraduate students.
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